Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions.

نویسندگان

  • Rajesh G Gonnade
  • Sekai Iwama
  • Ryusuke Sugiwake
  • Kochunnoonny Manoj
  • Hiroki Takahashi
  • Hirohito Tsue
  • Rui Tamura
چکیده

Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations.

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عنوان ژورنال:
  • Chemical communications

دوره 48 22  شماره 

صفحات  -

تاریخ انتشار 2012